Novo site do Programa: http://pgimuno.fmrp.usp.br

Laboratório de Imunoparasitologia

Equipe de pesquisa

Equipe de pesquisa:

Nosso laboratório está envolvido em elucidar os mecanismos que controlam a resposta imune inata e adaptativa durante a infecção por diversos patógenos e em processos inflamatórios crônicos. Nesse sentido, estudamos o envolvimento diversos leucócitos, citocinas, quimiocinas e seus respectivos receptores na mediação de resistência ou suscetibilidade de agentes infecciosos como Trypanosoma cruzi, Paracoccidiodes brasiliensis, Leishmania spToxoplasma gondii. Os mesmos mecanismos também são investigados no controle de determinados tipos de tumores, vírus e doenças auto-imunes.

 

- Mestrandos:

 

Frederico Ribeiro

Marcela Françoso

Marcela Davoli

Gustavo Quirino

Murilo Solano

Rodrigo Pereira

Natália Ketelut

 

- Doutorandos:

 

Fernanda Agostini

Tiago Medina

Manuela Sales

Laís Amorim

 

- Pós doutorandos:

 

Denise Fonseca

Luciana Benevides

Grace K. Silva

Maria Souza

Carla Duque

Daniela Carlos

Linhas de pesquisa

Imunoparasitologia

Sugestões de pesquisa

Silva GK, et al. ASC inflammasomes mediate IL-1b response and host resistance to Trypanosoma cruzi infection. The Journal of Immunology, 2013.

Sesti-Costa R, et al. The IL-33/ST2 Pathway Controls Coxsackievirus B5-Induced Experimental Pancreatitis. The Journal of Immunology, 2013.

Tristão FM, et al. 5-Lipoxygenase activity increases susceptibility to experimental Paracoccidioides brasiliensis infection. Infection and Immunity. 2013

Benevides L, et al. Enrichment of regulatory T cells in invasive breast tumor correlates with the upregulation of IL-17A expression and invasiveness of the tumor. European Journal of Immunology, 2013.

Guedes et al. Deficient regulatory T cell activity and low frequency of IL-17-producing T cells correlate with the extent of cardiomyopathy in human Chagas’ disease. Plos Neglected Tropical Diseases, 2012.

Gutierrez FR, et al. Regulation of Trypanosoma cruzi-induced myocarditis by programmed death cell receptor 1. Infection and Immunity, 2011.

Cavassani KA, et al. Cell-free antigens from Paracoccidioides brasiliensis drive IL-4 production and increase the severity of paracoccidioidomycosis. PLoS One, 2011.

Guedes PMM, et al. Nitric oxide donor trans-[RuCl([15]aneN(4))NO](2+) as a possible therapeutic approach for Chagas' disease. British Journal of Pharmacology, 2010.

Guedes PMM, et al. IL-17 Produced during Trypanosoma cruzi Infection Plays a Central Role in Regulating Parasite-Induced Myocarditis. Plos Neglected Tropical Diseases, 2010.

Garlet GP, et al. Regulatory T cells attenuate experimental periodontitis progression in mice. Journal of Clinical Periodontology, 2010

Campanelli, AP et al. Chemokines and chemokine receptors coordinate the inflammatory immune response in human cutaneous leishmaniasis. Human Immunology, 2010.

Cardoso CR, et al. Evidence of the presence of T helper type 17 cells in chronic lesions of human periodontal disease. Oral Microbiology and Immunology, 2009.

Moreira AP, et al.  CCR5-Dependent Regulatory T Cell Migration Mediates Fungal Survival and Severe Immunosupression. The Journal of Immunology (Baltimore), 2008.

Gutierrez FRS, et al. Increased Activities of Cardiac Matrix Metalloproteinases Matrix Metalloproteinase (MMP)-2 and MMP-9 Are Associated with Mortality during the Acute Phase of Experimental Trypanosoma cruzi Infection. The Journal of Infectious Diseases, 2008.

Cardoso CRB, et al. Characterization of CD4+CD25+ natural regulatory T cells in the inflammatory infiltrate of human chronic periodontitis.. Journal of Leukocyte Biology, 2008.

Benevides L, et al. CCR2 Receptor Is Essential to Activate Microbicidal Mechanisms to Control Toxoplasma gondii Infection in the Central Nervous System. The American Journal of Pathology, 2008.

Yamauchi LM, et al. The binding of CCL2 to the surface of Trypanosoma cruzi induces chemo-attraction and morphogenesis. Clinical and Experimental Immunology, 2007.

Campanelli AP, et al. CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells. The Journal of Infectious Diseases, 2006.

Cavassani KA, et al. Systemic and local characterization of regulatory T cells in a chronic fungal infection in humans. The Journal of Immunology (Baltimore), 2006.

Moreira AP, et al. Intercellular adhesion molecule-1 is required for the early formation of granulomas and participates in the resistance of mice to the infection with the fungus Paracoccidioides brasiliensis. The American Journal of Pathology, 2006.

Machado F, et al. CCR5 plays a critical role in the development of myocarditis and host protection in mice infected with Trypanosoma cruzi. The Journal of Infectious Diseases, 2005.

Galeria de Fotos

  • Laboratório de Imunoparasitologia

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